Home Americas Americas: CDC reports findings on antibiotic resistance in foodborne germs

Americas: CDC reports findings on antibiotic resistance in foodborne germs

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Antibiotic resistance in foodborne germs, an ongoing public health threat, showed both positive and troubling trends, according to data tracked by the Centers for Disease Control and Prevention (CDC) in 2012.

Each year, antibiotic-resistant infections from foodborne germs cause an estimated 430,000 illnesses in the US.

Multi-drug resistant salmonella, from food and other sources, causes about 100,000 illnesses in the country each year.

The most recent data showed that salmonella decreased during the past 10 years and resistance to two important groups of drugs – cephalosporins and fluoroquinolones – remained low in 2012.

However, in salmonella typhi, the germ that causes typhoid fever, resistance to quinolone drugs increased to 68% in 2012, raising concerns that one of the common treatments for typhoid fever may not work in many cases.

About one in five salmonella Heidelberg infections was resistant to ceftriaxone, a cephalapsorin drug.

This is the same salmonella serotype that has been linked to recent outbreaks associated with poultry.

Ceftriaxone resistance is a problem because it makes severe salmonella infections harder to treat, especially in children, says CDC.

The data are part of the latest report of the National Antimicrobial Resistance Monitoring System (NARMS), a tri-agency surveillance system that has tracked antibiotic resistance in humans (CDC), retail meats (Food and Drug Administration), and food animals (US Department of Agriculture) since 1996.

The report from CDC NARMS compares resistance levels in human samples in 2012 to a baseline period of 2003-2007.

“Our latest data show some progress in reducing resistance among some germs that make people sick but unfortunately we’re also seeing greater resistance in some pathogens, like certain types of salmonella,” said Robert Tauxe, deputy director of CDC’s division of foodborne, waterborne, and environmental diseases.

“Infections with antibiotic-resistant germs are often more severe. These data will help doctors prescribe treatments that work and to help CDC and our public health partners identify and stop outbreaks caused by resistant germs faster and protect people’s health.”

Report findings

Among the other findings in the 2012 report:

•Campylobacter resistance to ciprofloxacin remained at 25%, despite FDA’s 2005 withdrawal of its approval for the use of enrofloxacin in poultry.

Ciprofloxacin and enrofloxacin are both in the fluoroquinolone class of drugs.

•Shigella resistance to ciprofloxacin (2%) and azithromycin (4%) is growing.

However, no shigella strains were resistant to both drugs.

•Although fluoroquinolone resistance remained low in 2012, salmonella enteritidis – the most common salmonella type – accounted for 50% of infections resistant to the fluoroquinolone drug nalidixic acid, which is used in laboratory testing for resistance.

Resistance to nalidixic acid relates to decreased susceptibility to ciprofloxacin, a widely used fluoroquinolone drug.

Other work shows that many of the nalidixic acid resistant salmonella enteritidis infections are acquired during travel abroad.